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KMID : 1098420220300060462
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Korean Journal of Medicinal Crop Science
2022 Volume.30 No. 6 p.462 ~ p.480
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Plant-derived Anticancer Drugs and Research Trends of Plant Synthetic Biology for Production Improvement
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Park So-Young
Park Sang-Kyu
Vimalraj Mani
Lee Hyo
Lee Ki-Jong
Kim Beom-Gi
Lee Saet-Buyl
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Abstract
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Background: Plants are rich in phytochemicals, and their bioactive compounds have been employed in traditional medicine since ancient times. A variety of medicinal plant species and phy?tochemicals have been used to treat a wide range of chronic diseases, most notably, cancer.
Methods and Results: As the global prevalence of cancer increases, numerous investigations are being carried out to develop phytochemical-based medicines. For example, paclitaxel, camptothe?cin, vinca alkaloids, and podophyllotoxin are US Food and Drug Administration (FDA)-approved anticancer drugs derived from plants. However, plants contain only trace amounts of phytochemi?cals, which makes it difficult to supply them continuously. Moreover, their complicated structures hinder their ability to produce large quantities of chemicals for commercial use. Recently, research?ers have developed a number of biotechnological platforms to enhance the production of phytoch?micals.
Conclusions: In this review, we summarize the current status of four FDA-approved anticancer drugs derived from plants and provide plant biotechnology strategies, including synthetic biology, to facilitate their production.
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KEYWORD
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Anticancer Drugs, Camptothecin, Paciltaxel, Phytochemicals, Plant, Podophyllotoxin, Synthetic Biology, Vinblastine
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